TGFB1 and neoplasm: Tumor beds have been shown to mediate this immune suppression by secretion of tumor-derived soluble factors such as IL-10, transforming growth factor-β (TGF-β), IL-6, vascular endothelial growth factor (VEGF), prostaglandin E-2 (PGE-2), and gangliosides that act to prevent DC differentiation and function [14, 75].