The reduction of 6-OHDA-induced increase in immobility in the forced swim test by SR141716A was evident at the dose of 3 mg/kg but not at lower doses (0.5 and 1 mg/kg), suggesting that low doses of this CB1 antagonist may not be sufficient to induce antidepressant-like effect in this animal model of PD. Here, CNR1 is linked to Parkinson disease.