ACTA1 and Hepatic fibrosis: Hepatic stellate cell (HSC) proliferation and activation are thought to be crucial for the progression of liver fibrosis [3]; HSCs change from a quiescent status to activation and undergo transformation into myofibroblast-like cells which produce excessive extracellular matrix (ECM) proteins including α-smooth muscle actin (α-SMA) and type I collagen.