It has been demonstrated that berberine could suppress the MMP-2 expression in A 547 cells (a human non-small cell lung cancer cells with a highly metastatic capability) and inhibit MMP-9 expression in phorbol 12-myristate 13-acetate (PMA)-induced macrophages[10], [38], and berberine also could suppress migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibition of MMP-2 and MMP-9 [15]. The gene discussed is MMP2; the disease is non-small cell lung carcinoma.