Emerging transgenic murine models of CCMs involving spatial and temporal deletion of the CCM genes will assist in further understanding of the roles that Krit1/CCM1, MGC4607/CCM2 and PDCD10/CCM3 play in normal angiogenesis/vasculogenesis as well as pathological formation of vascular lesions. Here, PDCD10 is linked to cerebrocostomandibular syndrome.