Downregulation of miR-21 with a specific antisense oligonucleotide inhibits EGFR pathway and suppresses the growth of human GBM cells, independent of PTEN status.[11] Exploring the underlying mechanisms of miRNA action in glioma biology will provide novel therapeutic targets, and will be useful for the clinical management of this lethal and devastating neurological disorder. This evidence concerns the gene PTEN and nervous system disorder.