Supporting its putative involvement in the pathogenesis of the leprosy bacillus, Neill & Klebanoff have proposed that PGL-1 may be involved in the protection against oxygen radicals, as coating Staphylococcus aureus with purified PGL-1 or deacylated-PGL-1 increased its capacity to survive within human monocyte-derived macrophages and to resist in vitro to reactive oxygen species [9]. Here, SDHD is linked to leprosy.