A detailed phenotypic analysis revealed that treated tumors displayed no decrease in tumor cell proliferation (assayed by BrdU incorporation) as compared to vehicle-treated tumors (Figs. 2 A-C) but had a markedly elevated apoptotic index (assayed by TdT-mediated dUTP-biotin nick end-labeling [TUNEL] staining) (Figs. 2 D-F) and significantly decreased vascular density (assayed by counting FITC-lectin perfused vessels) (Figs. 2 G-I). This evidence concerns the gene DNTT and neoplasm.