Nonetheless, our results, combined with observations that (1) EGFR levels correlate with the malignant grade of endocrine tumors,42 (2) EGFR inhibitors increase apoptosis in a human PNET cell line,42 and (3) phosphorylated EGFR is detected in most human neuroendocrine tumors,24 suggest that some PNET patients may benefit from anti-EGFR therapy. This evidence concerns the gene EGFR and primitive neuroectodermal tumor.