The pathogenesisis more complex than that of SAC and PAC, and a leading role of an inflammatorynetwork not confined to the classical IgE-mast cell immediate hypersensitivityparadigm, but characterised mainly by Th2-type inflammation with mast cells, basophils,eosinophils, and polyclonal IgE activation, has been suggested. This evidence concerns the gene IGHE and gonorrhea.