Reported hazard ratios (HRs) for CAD for KIF6 p.Trp719Arg carriers were 1.18 (95% confidence interval [CI] 1.01-1.37; P=0.037) for CHD in the WHS[9], 1.57 (95% CI 1.10-2.25; P=0.01) for MI in the first analysis of the Cholesterol and Recurrent Events (CARE) study[5], and 1.27 (95% CI 0.97-1.66; P=0.08) for MI in patients with prior vascular disease and 0.83 (95% CI 0.60-1.14; P=0.25) in patients without prior vascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) trial[6]. This evidence concerns the gene KIF6 and myocardial infarction.