Recent work on mice harboring conditional knockout alleles of FoxO1 point to a potential role for FoxO TFs in the pathogenesis of Type 2 diabetes [17,18,19,20], cancer [14], and osteoporosis [16,42]; thus, it is conceivable that the EAK pathway may influence the pathogenesis of these aging-associated diseases. The gene discussed is FOXO1; the disease is type 2 diabetes mellitus.