Mechanisms whereby α-TEA induces tumor cells to undergo apoptosis include activation of both death receptors (Fas and DR5) and JNK/p73/Noxa pro-apoptotic pathways; as well as suppression of anti-apoptotic mediators Akt, ERK, c-FLIP and survivin [15,16,18,20,21,28,29]. The gene discussed is PMAIP1; the disease is neoplasm.