Previous studies utilizing various functional knockdown strategies (siRNA, neutralizing antibodies, transfection of dominant negative proteins and small chemical inhibitors) show that α-TEA-induced apoptosis in human breast, ovarian and prostate cancer cells is mediated by Fas and DR5 death receptor signal transduction via FADD or Daxx and involves both caspase-8 and mitochondrial-dependent signal transduction events [15,16,18,20,21]. This evidence concerns the gene TNFRSF10B and Familial prostate cancer.