APOB and coronary artery disorder: It has been suggested that flavonoids decrease the risk of coronary heart diseases by improving coronary vasodilatation, decreasing the ability of the platelets to clot, and preventing oxidation of low-density lipoproteins (LDL).79 Recent studies have shown that naringenin inhibits secretion of apoB and enhances LDL receptor-mediated apoB uptake.80 Hesperidin has similarly been reported to increase high-density lipoprotein (HDL) and lower LDL, plasma triglycerides and total lipids in rats.81