To define the roles for NORE1 in tumor growth, we initially evaluated effects of its expression on cellular growth using ectopic expression of wild-type (WT)-NORE1A and WT-NORE1B in Caco-2 and siRNA-mediated knockdown of endogenous NORE1A and NORE1B expression in HCT116. The gene discussed is RASSF5; the disease is neoplasm.