Together, these results demonstrate that both NORE1A and NORE1B expression is frequently down-regulated in colorectal cancer cells at the transcript level, and NORE1A is more commonly down-regulated compared to NORE1B. Likely cancer cell lines, primary tumors expressed variable levels of NORE1A and NORE1B, and a substantial fraction of tumors showed a marked reduction in expression of both transcripts (Figure 1C). Here, RASSF5 is linked to cancer.