Furthermore, NORE1A reduction was significantly high in stage III tumor (19 of 36, 52.8%) compared with stage I and II tumors (7 of 26, 26.9% and 5 of 18, 27.8%, respectively) (P < 0.05) and more frequent in poorly differentiated tumors (6 of 9, 66.7%) than well and moderately differentiated tumors (9 of 25, 36% and 16 of 46, 34.8%, respectively) (P < 0.05) (Figure 3A). The gene discussed is RASSF5; the disease is neoplasm.