Lung injury-related genes (HMGB1, MUC1 and VWF), proinflammation-related genes (MMP, CRP, and HMGB1), coagulation-related genes, immunoreactive genes (PBEF1 and TNF-α), fibrosis-related gene (TGF-β), wound-healing related gene (PDGFA), and cancer-related genes (MUC1 and hTERT) have been reported previously to correlate with the onset of ARDS or SIRS and subsequent survival. This evidence concerns the gene HMGB1 and systemic inflammatory response syndrome.