Lung injury-related genes (HMGB1, MUC1 and VWF), proinflammation-related genes (MMP, CRP, and HMGB1), coagulation-related genes, immunoreactive genes (PBEF1 and TNF-α), fibrosis-related gene (TGF-β), wound-healing related gene (PDGFA), and cancer-related genes (MUC1 and hTERT) have been reported previously to correlate with the onset of ARDS or SIRS and subsequent survival. The gene discussed is TNF; the disease is systemic inflammatory response syndrome.