Among the 21 predicted factors, except for the controversial −46C/C in DARC, SNPs in CCR1, CCBP2, HTR6, HTR1B, HTR1E, CSF3R, IL1R1, TNFRSF5 are associated with one or more clinical phenotypes but their relation to HIV infection has not been investigated. The gene discussed is ACKR1; the disease is HIV infectious disease.