Among the 21 predicted factors, except for the controversial −46C/C in DARC, SNPs in CCR1, CCBP2, HTR6, HTR1B, HTR1E, CSF3R, IL1R1, TNFRSF5 are associated with one or more clinical phenotypes but their relation to HIV infection has not been investigated. This evidence concerns the gene IL1R1 and HIV infectious disease.