IFNG and mucocutaneous leishmaniasis: There is evidence demonstrating CD4+ T cells collected from patients with CL or mucocutaneous leishmaniasis (ML) or individuals with history of CL produced a high level of IFN-γ in response to Leishmania antigens which is an indication of a Th1 like response [10], [11]; Conversely, T cells from patients with diffuse CL (DCL) failed to express IL-2 receptor and did not produce IFN-γ in response to Leishmania antigens, whereas IL-4 mRNA markedly increased in DCL lesions [17], [18].