When the 50 women who developed preeclampsia were excluded from the group with prior preeclampsia, sFlt1 was significantly lower in smokers compared to nonsmokers (2.4 vs 3.1 ng/ml, p = 0.02), but the relationship of PlGF and sEng between smokers and nonsmokers remained the same. The gene discussed is PGF; the disease is preeclampsia.