The major findings of our study were (1) maternal sFlt1 concentrations are not reduced with smoking, (2) smoking is associated with changes in circulating PlGF and sEng concentrations toward a pro-angiogenic direction but these differences were not consistent across all high risk groups, and (3) smoking in early pregnancy is not associated with a reduced incidence of preeclampsia. Here, PGF is linked to preeclampsia.