The direct evidence of SOD1 in muscular atrophy was recently reported by Muller et al. [48], where they showed a dramatic increase in mitochondrial reactive oxygen species (ROS) in three conditions of muscular atrophy in animals lacking Sod1. In another study, mutations in Sod1gene (SOD1G93A) selectively in skeletal muscle showed progressive muscle atrophy with concomitant reduction in muscle strength, alterations in contractile apparatus, and mitochondrial dysfunction [49]. This evidence concerns the gene SOD1 and muscular atrophy.