Our findings with the human colon cancer cell line Caco-2 agreed well with previous studies on the human hepatoma HepG2 cell line co-transfected with HNF6 or its deletion mutants as well as FOXA1, FOXA2, or FOXA3 TATA-luciferase reporter constructs [18]. This evidence concerns the gene ONECUT1 and malignant colon neoplasm.