Understanding the role of BDNF/TrkB signaling in AD pathogenesis could be of great clinical and public health importance since BDNF is inducible and may be one of the key molecules mediating the beneficial effect of certain lifestyle measures (lower caloric intake, increased aerobic physical activity, environmental enrichment)[40]–[42]on the risk of developing dementia. The gene discussed is BDNF; the disease is Alzheimer disease.