We first tested for association between each SNP and the risk of CRC (vs. controls), MSI-H CRCs (vs. MSS/L CRCs), MLH1 IHC-deficient CRCs (vs. MLH1 IHC-positive), and with MLH1 promoter methylation (vs. unmethylated MLH1 promoter) (Supplementary File S2). The gene discussed is MLH1; the disease is colorectal carcinoma.