To address this question, in the present study, serum levels of free and dissociated (total) autoAbs reacting with hypocretin-1 peptide were measured in patients with central hypersomnias (including narcolepsy-cataplexy, narcolepsy without cataplexy and idiopathic hypersomnia) and compared to healthy subjects and to biological and clinical parameters relevant to sleep disorders. Here, HCRT is linked to narcolepsy.