KDR and neoplasm: It has been reported that phenolic compounds such as ellagic acids, EGCG, genistein and anthocyanin-rich berry extracts inhibit tumor angiogenesis through down-regulation of vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), platelet-derived growth factor (PDGF), PDGF receptor (PDGFR), hypoxia-inducible factor 1α (HIF-1α) and MMPs, as well as inhibition of phosphorylation of EGFR, VEGFR and PDGFR [235].