Following intravenous administration of 1 × 1010 virus particles/mouse, PSGL-1-Fc-StrepGpcAdluc efficiently accumulated in HepG2 human tumour xenografts implanted subcutaneously into CD1 nude mice, with an overall ratio of 345.5-, 36- and 43.7-fold higher virus genomic copies compared with StrepGpcAdluc, Adluc and the IgG1-Fc-StrepG-modified control virus, respectively (Fig. 5b). This evidence concerns the gene SELPLG and neoplasm.