Furthermore, infection in the presence of competing free MHES monoclonal antibody (intended to outcompete binding for E-selectin), resulted in almost 5-fold less transgene expression in HUVECs transduced with the MHES-retargeted virus; while Adluc, protein G-modified and IgG-control viruses remained unaffected by E-selectin blockade. The gene discussed is SELE; the disease is infection.