For further analysis of the relationship between the IL-18 gene promoter polymorphisms and PCOS IR, the PCOS patients were again divided into two sub-groups: PCOS with hyperandrogenism: T ≥ 2.8 nmol/L; PCOS without hyperandrogenism: T < 2.8 nmol/L. This evidence concerns the gene IL18 and hyperandrogenism.