FRD rats, however, had significantly higher plasma triglyceride, fructosamine and insulin levels (1.61 ± 0.14 vs. 1.13 ± 0.08 mmol/L, P < 0.02; 162.6 ± 3.3 vs. 146.2 ± 5.6 μmol/L, P < 0.03; 1.12 ± 0.04 vs. 0.86 ± 0.10, P < 0.05) as well as HOMA insulin resistance index (7.66 ± 0.31 vs. 5.16 ± 0.21, P < 0.001, respectively) than CD rats. The gene discussed is INS; the disease is Insulin resistance.