According to Ribeiro et al. [1]3 CK16 is found in tissues under hyperproliferation, such as in benign hyperproliferative epidermal diseases (common wart, psoriasis, actinic keratosis and seborrheic dermatitis) and in tissues under healing stages and in malignant epidermal diseases such as squamous cell carcinoma. This evidence concerns the gene KRT16 and squamous cell carcinoma.