Similarly, a report on an extended series with a longer follow-up of women with BRCA1/2 mutation having undergone PBM at the Rotterdam Family Cancer Clinic found that no primary breast cancer occurred after PBM after a median follow-up of 4.5 years, with one woman presenting metastatic breast cancer almost four years after her PBM where no primary was found[75]. This evidence concerns the gene BRCA1 and breast carcinoma.