Intense fragmentation of elastin has been observed at the invasive front of melanoma and in vitro studies suggested that EDPs could participate to such a process in vivo by inducing proteolytic cascades (Yusa et al, 1989; Timar et al, 1991; Svitkina and Parsons, 1993; Ntayi et al, 2004). The gene discussed is ELN; the disease is melanoma.