These results indicate that anti-IGFBP7 sdAb detects its target, IGFBP7, in both mouse and human GBM tissue sections ex vivo. This analysis confirms our previous observation of a selective vascular upregulation of IGFBP7 in human GBM (Pen et al, 2007) and demonstrates that mouse vessels ingrowing into orthotopically implanted human GBM (U87MG-EGFRvIII) are selectively induced by the tumour microenvironment to overexpress IGFBP7. The gene discussed is IGFBP7; the disease is neoplasm.