In surgically removed human GBM tissue, IGFBP7 immunoreactivity (Figure 2C, middle panel) colocalised with highly abnormal tumour vasculature stained with Ulex europeaus agglutinin I (UEA I) (Figure 2C, right panel), shown previously to selectively bind to carbohydrates of human brain vessels (Holthofer et al, 1982). The gene discussed is IGFBP7; the disease is neoplasm.