IGFBP7 and glioblastoma: In surgically removed human GBM tissue, IGFBP7 immunoreactivity (Figure 2C, middle panel) colocalised with highly abnormal tumour vasculature stained with Ulex europeaus agglutinin I (UEA I) (Figure 2C, right panel), shown previously to selectively bind to carbohydrates of human brain vessels (Holthofer et al, 1982).