In addition, anti-IGFBP7 sdAb was shown to target PEGylated superparamagnetic nanoparticles (NPs) (T2-reducing MRI contrast agents) functionalised with the near-infrared probe Cy5.5 for optical detection, to the vessels of orthotopic brain tumour in mice, creating high tumour-contralateral side signal-to-noise ratio and selective tumour accumulation compared with other organs in prospective in vivo optical imaging. This evidence concerns the gene IGFBP7 and brain neoplasm.