Several studies demonstrated that IGFBP7 is overexpressed in tumour blood vessels with little or no expression in normal blood vessels (Akaogi et al, 1996; St Croix et al, 2000; Pen et al, 2007), nor in the non-malignant angiogenic placental tissues (van Beijnum et al, 2006). This evidence concerns the gene IGFBP7 and neoplasm.