On the other hand, SAHA has been shown previously to disrupt bortezomib-induced aggresome formation in MM cells (Nawrocki et al, 2008) as a result of the destruction of HDAC6, which promotes aggresome inclusion of misfolded polyubiquitylated proteins on the dynein motor complexes along the MTs (Kawaguchi et al, 2003). The gene discussed is HDAC6; the disease is Miyoshi myopathy.