Interestingly, the genes Gata6, Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) and Bhlhb2 (basic helix-loop-helix domain containing, class B2) were down-regulated in ICC and HCA as well as the 52 week expression profiles of TCDD and/or PCB126, but not PCB153. This evidence concerns the gene AGT and intrahepatic cholangiocarcinoma.