The C57BL/6 syngeneic mouse ovarian cancer model developed by Roby et al, [10] has been used for studies of the contribution of cells in the tumor microenvironment, including epithelial-stromal cell interactions, VEGF induced-effects on tumor vasculature and tumor cell-secreted factors that stimulate cytokine production, macrophage infiltration and vascularization that favor tumor growth and progression [14,15,18]. The gene discussed is VEGFA; the disease is ovarian carcinoma.