Constitutively active NFATc isoforms have been shown to promote induction and progression of both hematological malignancies and solid tumors by driving synthesis and secretion of pro-angiogenic factors (e.g. cyclo-oxygenase 2 and tissue factor) as well as factors promoting cell motility (e.g. lysophosphatic acid and prostaglandin E2). This evidence concerns the gene PTGS2 and hematologic disorder.