IL13 and Increased total eosinophil count: Administration of recombinant IL-13 directly to the mouse airway, or transgenic over-expression of IL-13 in the airway, is sufficient to induce a phenotype resembling human asthma pathology, characterised by eosinophilia, airway remodelling, goblet cell upregulation, mucus hypersecretion and AHR [18]–[21].