Seven of these are induced by interferon: OAS1, ISG15, IRF7, OASL, ICAM1, IFITM1, and IFIT3. These 7 ISGs have already been found upregulated together with other interferon genes upon H1N1 PR8 endothelial primary cell cultures infection [37] (Table S5). The gene discussed is IFIT3; the disease is infection.