In the Geo database many Slc39a4 data sets did not reveal significant differences between normal and cancer samples, but evidence suggested elevated Zip4 mRNA is found in some lymphoma, melanoma and metastatic colon cancer data sets and in data sets from two mouse models of HCC (Mdr2 knockout and Trnip transgenic). The gene discussed is SLC39A4; the disease is hepatocellular carcinoma.