Inhibition of hydroxyacid oxidase 2 (HAO2) in the reduced kidney model led to reduced glutamate, glycine, and serine reabsorption suggesting a possible role for HAO2 in the hypertensive side effect following CETP inhibitor treatment based on the association of amino acid reabsorption with vasodilation and hypertension (see Table 1). This evidence concerns the gene HAO2 and Hypertension.