It is possible that the treatment time that we employed (8 weeks) is not sufficient for producing the visible alterations corresponding to fluorosis, in leukocytes as well as at the general level; however, the changes found in metabolic activity, as well as in the expression of proteins p53 and caspase-3, demonstrate to us that there are metabolic changes in peripheral blood leukocytes that are produced by our treatment. Here, CASP3 is linked to dental fluorosis.