APOBEC3G and chronic hepatitis B virus infection: With different responses to antiviral therapy with IFN-α, the differences of STAT-1 expression in the liver tissues of patients with chronic hepatitis B were observed, in order to investigate whether the JAK-STAT signal pathway participates in the regulation of APOBEC3G gene transcription and to study the molecular mechanisms of IFN resistance in patients with chronic hepatitis B.