With different responses to antiviral therapy with IFN-α, the differences of STAT-1 expression in the liver tissues of patients with chronic hepatitis B were observed, in order to investigate whether the JAK-STAT signal pathway participates in the regulation of APOBEC3G gene transcription and to study the molecular mechanisms of IFN resistance in patients with chronic hepatitis B. This evidence concerns the gene IFNA1 and chronic hepatitis B virus infection.