PRRT2 and multiple sclerosis: PKCθ is of such importance in the activation and survival of T cells that PKCθ knockout (KO) mice have been reported to have diminished responses in various T cell-mediated disease models, including the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis [2,3], the type II collagen-induced arthritis (CIA) model [4], etc. Furthermore, these mice exhibited significantly increased survival following a cardiac allograft transplantation, suggesting a potential utility of PKCθ inhibitors as immunosuppressives following transplantation [5].