Activation of p38α leads to the up-regulation of both TNFα and IL-1β, resulting in many chronic inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease, Crohn’s disease, and chronic obstructive pulmonary disease (COPD), as well as the other inflammatory disorders [4–8]. The gene discussed is IL1B; the disease is chronic obstructive pulmonary disease.