Analyzing the protein profiles of colon cancer serum and protein profiles of CRC tumors demonstrated that human neutrophil peptides (HNP)-1, HNP-2 and HNP-3, also known as a-defensin-1, adefensin-2, and a-defensin-3, are up-regulated in CRC patients [76. The gene discussed is DEFA3; the disease is colorectal carcinoma.