SND1 and malignant colon neoplasm: As to CRC, Dr. Nakagama’s group [55,56] has demonstrated that Staphylococcal nuclease homology domain 1 (SND1), a component of RISC, is frequently up-regulated in human colon cancers and also chemically-induced colon cancers in animals, as well as in preneoplastic lesions of the colon.