A large population-based study revealed that a fecal DNA panel consisting of 21 mutations (three in the K-ras gene, 10 in the APC gene, and eight in the p53 gene; the MSI markers of BAT-26; and L-DNA) detects a greater proportion of CRC than FOBT without compromising specificity [29]. Here, TP53 is linked to colorectal carcinoma.