Further, when icatibant was co-administered with the ACE inhibitor perindoprilat the normal reduction in mean arterial pressure was attenuated despite no effect on neurohormonal responses to perindoprilat.15 Similarly, vasodilation in response to acetylcholine and bradykinin is blunted in resistance arteries of the forearm in patients with coronary artery disease with or without left ventricular dysfunction. Here, ACE is linked to coronary artery disorder.