Activation of AhR activity by TCDD has been shown to suppress autoimmune disease development, including that of type 1 diabetes and Experimental Autoimmune Encephalomyelitis.[15], [40], [41], [42], [43], [44] However, clinical use of TCDD is unlikely due to its history as an environmental toxicant. The gene discussed is AHR; the disease is type 1 diabetes mellitus.