ALK, PHOX2B and PHOX2A resulted to be highly expressed in almost all analyzed NB cell lines (Figure 1) with respect to a pool of normal tissues and to HeLa cells, a cervix carcinoma cell line characterized by low level of ALK expression [31] and almost undetectable expression levels of the two PHOX2 genes [6]. The gene discussed is PHOX2B; the disease is neuroblastoma.