Here, a number of compelling evidences are reported, demonstrating extensive co-regulated over-expression of PHOX2A, PHOX2B and ALK in NB cell lines and a novel PHOX2B-mediated effect on ALK transcriptional induction, sustained by PHOX2B binding the ALK promoter region, thus establishing ALK as a novel PHOX2B target gene. Here, PHOX2B is linked to neuroblastoma.