This result is expected since MMP14 (also known as MT1-MMP) and TIMP-2 are specifically involved in the cell surface mechanism to activate proMMP-2[35], [36], that essentially contributes to the promoting the invasive capacity of tumor cells[35] and mesenchymal stem cells[37], and it is also known that MMP16 (MT3-MMP) activates MMP2 by cleavage of proMMP-2[38]. This evidence concerns the gene MMP16 and neoplasm.