As to the possible mechanisms of PZH protective effects on ischemia and stroke, proteomic results indicated that the cytochrome b-c1 complex subunit 2 (QCR2) was down-regulated in the ischemia with PZH treatment group in both the hippocampus and cerebellum as compared to the ischemia control group (Tables 5 and 6). This evidence concerns the gene UQCRC2 and Stroke.