Similarly, BPI was applied to monitor bacterial loads in wild-type and knockout mice infected with bioluminescent C. rodentium to study the role of MyD88 and the p50 subunit of the transcription factor nuclear factor kappa B (NF-κB) during gastrointestinal infections (Dennis et al., 2008; Gibson et al., 2008;). The gene discussed is NFKB1; the disease is digestive system infectious disorder.